Lymphoepitheliomalike carcinoma, abbreviated lelc, is a rare, poorly differentiated, malignant epithelial tumour it can be considered a subtype of squamous carcinoma aka squamous cell carcinoma. The treatment for lymphoepithelial carcinoma of salivary gland involves a combination of surgery, chemotherapy, and radiation therapy, in most cases. Although such tumours are well described in the cervix this is only the second report of such a neoplasm at this site. Our first case is a 30yearold man with lec in the left maxillary sinus. He is now at 9months followup period, with no evidence of disease. Nov 25, 2017 lymphoepithelial carcinoma is a tumor mostly diagnosed in the nasopharynx, but it has also been described in a variety of nonnasopharyngeal sites. Lymphoepitheliomalike carcinoma lelc of the salivary gland is a rare tumor. The most common location of lec is the nasopharynx. The histogenesis of lelcs remains controversial as to whether it has adnexal origin or represents an inflamed squamous cell carcinoma scc.
Although clinically significant because of its malignant nature, it is difficult to make a differential diagnosis by preoperative imaging. Investigations revealed a muscleinvasive lymphoepitheliomalike carcinoma of. In western countries, salivary gland lymphoepithelial like carcinomas are uncommon and only 14 cases have been described so far. Lymphoepitheliomalike carcinoma of the vagina journal. Lymphoepithelial carcinoma is a rare tumor of the salivary gland of exceptionally high incidence among eskimo. Furthermore for the salivary plec have been used different terms as. Lymphoepithelial carcinoma schmincke type as a derivate.
We report a case of a lymphoepithelial carcinoma developing in a minor salivary gland of the oral cavity in a 69yearold woman. Pdf lymphoepithelial carcinoma of the submandibular. The lymphoepithelial carcinoma of the nasopharynx is strongly associated with infection with the epsteinbarr virus ebv. The lesion is histologically identical to undifferentiated nasopharyngeal carcinoma lymphoepithelioma, but with epsteinbarr virus involvement. Epsteinbarr virusassociated lymphoepithelial carcinoma has been exceptionally reported. Four others had foci of both lec and conventional squamous cell carcinoma.
Two subsets of gastric cancer, epsteinbarr virus ebvpositive and microsatellite instability msihigh cancers, have been. Pdf lymphoepithelial carcinoma of the salivary glands. Lymphoepitheliomalike carcinoma is a rare tumor of the bladder for which the therapeutic strategy is not clearly defined. Lymphoepithelial carcinoma of the minor salivary gland jama. A multicenter analysis of genomic profiles and pdl1.
The histogenesis of lelcs remains controversial as to whether it has adnexal origin or represents an inflamed squamous cell carcinoma scc histology of lymphoepitheliomalike carcinoma. Lymphoepitheliallike carcinomas of the head and neck. It constitutes about 4% of all gastric carcinomas 3, 4. Investigations revealed a muscleinvasive lymphoepitheliomalike carcinoma of the bladder. Poorly differentiated nonkeratinizing squamous cell carcinoma of the thymus, also known as lymphoepitheliomalike carcinoma, is a rare primary malignant neoplasm of thymic origin. Dec 11, 2012 lymphoepithelial carcinoma of the maxillary sinus is a very rare malignancy and it can be difficult to make a preoperative diagnosis. In the present article, we describe in detail the clinical and histopathologic features of a primary lacrimal gland lymphoepithelial carcinoma with immunohistochemical and molecular analysis.
Lelcb is characterized by a marked infiltration of lymphocytes in the area involved by the tumor which may coexist with the conventional urothelial. Lymphoepithelial carcinoma malignant lymphoepithelial lesion. Primary lymphoepithelial carcinoma of the nasopharynx. However, it can also occur in other organs including the salivary glands, particularly the parotid and submandibular glands.
Lymphoepitheliomalike carcinoma of head and neck skin. Lec can occur in many organs, but is most common in head and neck regions including pharynx. The majority of cases involve the parotid gland, presenting as single or multiple masses. Strong nuclear staining with erg in lymphoepitheliomalike carcinoma immunohistochemical stain. Lymphoepitheliallike carcinomas of the head and neck are histologically similar to nasopharyngeal carcinoma nonkeratinizing undifferentiated type but by definition arise in mucosal sites other than the nasopharynx.
Skin nonmelanocytic tumors lymphoepitheliomalike carcinoma. Lymphoepithelioma an overview sciencedirect topics. A majority of lymphoepithelial carcinoma originates from the nasopharynx, but some will involve the lung, salivary glands, stomach, urinary tract. A 72yearold caucasian woman presented to our facility with an isolated rightside epistaxis that had been present for three months, with the results of a computed tomography scan showing a soft tissue mass in the right maxillary sinus with an impacted tooth. The tumor showed no evidence of recurrence or metastasis at clinical follow. Endoscopic excision of the tumor was performed and the final histological examination was compatible with sinonasal lymphoepithelial carcinoma. The patient was then referred to the oncology team for further management in view of postoperative. Researched pathways related to lymphoepithelial carcinoma include pathogenesis, localization, cell differentiation, oncogenesis, immune response. The study of lymphoepithelial carcinoma has been mentioned in research publications which can be found using our bioinformatics tool below. Lymphoepitheliomalike, a variant of urothelial carcinoma. Lymphoepitheliomalike carcinoma of the skin lelcs is a very rare primary skin neoplasm that most frequently occurs on the sunexposed skin of the head and neck in elderly individuals. Lymphoepithelial carcinoma, which is a variant of undifferentiated carcinoma, is distinguished from small cell and large cell undifferentiated carcinoma by its association with benign lymphoepithelial lesions. Lymphoepithelioma is also known as class iii nasopharyngeal carcinoma in the who classification system. Due to its rare occurrence, prognoses and ideal treatment guidelines have not been clearly defined.
Lymphoepithelial carcinoma is a tumor mostly diagnosed in the nasopharynx, but it has also been described in a variety of nonnasopharyngeal sites. Primary lymphoepitheliallike carcinoma of the parotid. Cytokeratin positive derived from the kidney parenchyma gata3 is expressed not associated with epsteinbarr virus in contrast to nasopharyngeal carcinoma. However, in contrast to other highgrade salivary gland carcinomas, lelcs are considered radiosensitive. It is extremely rare in the larynx and should be distinguished from squamous cell carcinoma. Lymphoepitheliomalike carcinoma llc of the stomach is a rare and peculiar type of gastric carcinoma that was first described by watanabe et al in 1976 as gastric carcinoma with a lymphoid stroma 1, 2. Lymphoepitheliomalike carcinoma of the salivary gland. Lymphoepitheliomalike carcinoma of the skin lelcs is a rare tumor of unknown etiology, low malignant potential, and microscopic resemblance to. Conclusion lymphoepithelial like carcinoma occurring in the reproductive organs is a rare variant of squamous cell carcinoma, and this tumor of the uterine cervix accounts for 0, 7% of all primary cervical uterine neoplasms. Pathology outlines lymphoepitheliomalike carcinoma. Lymphoepithelial like carcinomas of the head and neck are histologically similar to nasopharyngeal carcinoma nonkeratinizing undifferentiated type but by definition arise in mucosal sites other than the nasopharynx.
In this communication a case of thymic carcinoma with lymphoepithelial. Lymphoepithelial carcinoma of the larynx and hypopharynx. Lymphoepithelial carcinoma of the minor salivary gland. Lymphoepithelial sialadenitis, hivassociated salivary gland disease, chronic sclerosing sialadenitis, warthin tumor, and extranodal marginal. Which statement about lymphoepitheliomalike carcinoma of the urinary tract is false. Controversies exist in the current literature regarding the treatment of lymphoepithelial carcinoma lec.
Rare pdf lymphoepithelial carcinoma lec is most commonly seen in the nasopharynx. Magnetic resonance imaging revealed a large well defined symmetrical soft tissue mass lesion arising from the mucosa of the nasopharynx. There is strong association with epsteinbarr virus ebv infection. Currently, surgery with or without radiotherapy is the recommended treatment for all salivary gland carcinomas. Department of pathology, lbj general hospital, 5656 kelley street, 3pa 93002a. Lymphoepitheliomalike carcinoma pathology dermnet nz.
Lymphoepithelial carcinoma lec is an uncommon malignant neoplasm characterized by undifferentiated malignant epithelial cells with marked infiltration of lymphoid cells in the stroma. Thymoma is only rarely reported within the thyroid gland. Lymphoepithelial carcinoma of the maxillary sinus is a very rare malignancy and it can be difficult to make a preoperative diagnosis. Lymphoepithelial carcinoma arising from the maxillary antrum.
Jul 15, 20 primary lymphoepithelial like carcinoma of the parotid gland is a rare tumour with an increased incidence among eskimos and orientals. Lymphoepitheliomalike carcinoma of the bladder lelcb is a rare variant of urothelial carcinoma first described by zukerberg in 1991 and confirmed as a variant of urothelial carcinoma by the who classification of tumors of the urinary system. Lymphoepithelial carcinoma lec, also called lymphoepitheliomalike carcinoma, is defined as an undifferentiated carcinoma or poorly differentiated squamous cell carcinoma, accompanied by a prominent reactive lymphoplasmacytic infiltrate. First reported in 1991, bladder lelc has an incidence of about 1% of all bladder carcinomas. In western countries, salivary gland lymphoepitheliallike carcinomas are uncommon and only 14 cases have been described so far. Jun 23, 2011 lymphoepithelial carcinoma lec is a rare malignancy.
Lymphoid lesions of salivary glands lymphoid lesions of salivary glands. Lymphoepitheliomalike carcinoma of the vagina journal of. Lymphoepitheliallike carcinoma of the parotid gland. Most cases of lymphoepithelial carcinoma behave as intermediate to highgrade malignancies. Download this article belongs to volume 25, issue 1. Ten tumours of tonsillar or epipharyngeal localization showing the histological picture of lymphoepithelial carcinoma schmincke 1921 were examined immunohistochemically using peanut lectin, ulex europaeus lectini and an antiserum to s100 protein. Most cases of lec occur in the nasopharynx and are pathologically classified as a nonkeratinizing undifferentiated type of nasopharyngeal. Its morphologic and pathological features are similar to those of nasopharyngeal lymphoepithelial carcinoma. Histology showed a well circumscribed lesion composed of syncytial sheets of epithelioid tumour cells with an intense inflammatory infiltrate, largely consisting of t lymphoid cells. Pdf lymphoepithelial carcinoma of parotid gland a case report. Lymphoepitheliomalike carcinoma lelc is a rare highgrade carcinoma that resembles nasopharyngeal lymphoepithelioma and can occur throughout the body. We report the case of a 64yearold moroccan man who presented with macroscopic hematuria.
Lymphoepithelial carcinoma of the parotid gland, head. Lymphoepithelial carcinoma of the larynx is an extremely rare disease, with an aggressive pattern. Lymphoepithelial carcinoma of the salivary glands ncbi. There are only a few published reports of radiotherapy alone for the treatment. Lymphoepithelial carcinoma of parotid gland a case report. Case report epsteinbarr virus associated lymphoepithelial.
The ulcerations represent punch biopsies figure 2 an invasive carcinoma originates from the epidermis and pen. Epsteinbarr virus negative lymphoepithelial carcinoma of. The presented study summaries the literature controversies in the treatment of lec and present a case of a rare lec diagnosed in the sublingual gland of an otherwise healthy 21yearold arab woman. Lymphoepithelial carcinoma lec of the larynx is a neoplasm that is located in most of the cases in the nasopharynx, where it represents 40% of all tumors. Poorly differentiated nonkeratinizing squamous cell carcinoma of the thymus, also known as lymphoepitheliomalike carcinoma, is a rare primary malignant neoplasm of. A form of cancer, carcinoma makes up the majority of the cases of malignancy of the breast, uterus, intestinal tract, skin, and tongue. The prognosis of the individual depends upon a set of several factors including the tumor stage and overall health of the individual. The tumor they described could be the first reported case of lymphoepithelial carcinoma. Lymphoepithelial carcinoma is a rare variant of anaplastic carcinoma, that accounts for less than 0.
Expression of pdl1pd1 in lymphoepitheliomalike carcinoma. The patient was disease free for four years then she had primary lung recurrence which was surgically resected. Primary lymphoepitheliallike carcinoma of the parotid gland is a rare tumour with an increased incidence among eskimos and orientals. Lymphoepitheliomalike carcinoma of the prostate request pdf. Lymphoepithelial carcinoma lec consists of poorly differentiated squamous cell carcinoma or histologically undifferentiated carcinoma accompanied by prominent reactive lymphoplasmacytic infiltration. Well circumscribed lobules, nests or small aggregates of large, cohesive, epithelioid cells closely associated with a dense, mixed t and b lymphocytic and plasmacytic infiltrate rare tumors 20. There are only a few published reports of radiotherapy alone for the treatment of.
Pdf lymphoepitheliomalike carcinoma of the skin researchgate. In this case report, we discuss its etiopathogeny, its epidemiological, clinical. Lymphoepithelial carcinoma lec is an uncommon malignant tumor composed of undifferentiated malignant epithelial cells with characteristic lymphoid stroma. He is currently on clinical surveillance, showing no signs of active disease at 9 months of followup. Lymphoepithelial carcinoma definition of lymphoepithelial. Ep415 lymphoepithelial cervical carcinoma international. E590 14 cases of the renal pelvis, including 7 case reports and 2 small case series.
All eight tumors exhibited alterations in p53 expression, but none was positive for. Pdf lymphoepithelial carcinoma lec is most commonly seen in the nasopharynx. It has a high tendency to metastasize and is responsive to radiotherapy. In these populations, it is usually associated with epsteinbarr virus. Histologically, it is an undifferentiated carcinoma with an intermixed reactive lymphoplasmacytic infiltrate. Lymphoepithelial carcinoma lec is a rare variant of undifferentiated carcinoma that accounts for less than 0. The prognosis of lelc is thought to be better than those of other cervical cancer types, but careful followup at fixed. Dec 14, 2014 lymphoepitheliomalike carcinoma is a rare tumor of the bladder for which the therapeutic strategy is not clearly defined. Lymphoepithelial carcinoma of the lacrimal gland external. Lymphoepithelial carcinoma lec is a rare malignancy with the histopathological feature of undifferentiated carcinoma and an intermixed reactive lymphoplasmacytic infiltration.
Lymphoepitheliomalike carcinoma of the skin can j plast surg vol 10 no 5 novemberdecember 2002 221 figure 1lymphoepitheliomalike carcinoma of the skin on the upper arm of a 38yearold woman just before excisional biopsy. Lymphoepitheliomalike carcinoma lelc of the prostate. The patient underwent local and systemic treatment for metastatic disease with good clinical outcome. Ibrahimov m, yilmaz m, celal mh, mamanov m, yollu u, ozek h. Lymphoepithelial carcinoma arising from the maxillary. Epsteinbarr virusassociated with lymphoepithelial carcinoma. Lymphoepithelial carcinoma affects children and adults and presents at a mean age of approximately 55 years. Pdf primary cutaneous lymphoepitheliomalike carcinoma is a rare disease with low metastatic potential.
The findings suggest a close relationship of this type of carcinoma to the normal tonsillar crypt epithelium. Lymphoepitheliomalike carcinoma of the bladder is an uncommon neoplasm, of which 49 cases have been described in the english literature, none of which has been studied for p53 protein expression. A case of lymphoepithelial carcinoma lec occurring in right submandibular gland of a yearold indian male is presented, wherein the lesion unveiled itself only after multiple fine needle. Herein, we report two cases of lec in the head and neck region that presented to oulu university hospital. This report describes a lymphoepitheliomalike carcinoma of the vagina. Pdf background lymphoepithelial carcinoma is a tumor mostly diagnosed in the nasopharynx, but it has also been described in a. Adjunct professor, university of utah school of medicine. This is a case of metastatic lung cancer of the lymphoepitheliallike carcinoma lelc variant who first presented with symptomatic brain metastasis. Lymphoepithelial carcinoma lec of the oral cavity and pharynx is uncommon, and the.
Who gets lymphoepithelial carcinoma of salivary gland. Primary lymphoepithelial carcinoma plec is a rare subtype of salivary gland cancers, which comprises only 0. We report a case of a 76yearold woman, presented with a primary lymphoepithelial carcinoma of the parotid gland. Primary lymphoepitheliallike carcinoma of the parotid gland. Primary lymphoepithelial carcinoma of the parotid gland is a rare tumor with an increased incidence among eskimos and orientals. Therefore, it must be known by clinicians, pathologists and oncologists. Lymphoepitheliomalike carcinoma lelc is a medical term referring to a histological variant of malignant tumor arising from the uncontrolled mitosis of transformed cells originating in epithelial tissue or in cells that display epithelial characteristics that bear microscopic resemblance to lymphoepithelioma nasopharyngeal carcinoma. Pdf lymphoepithelial carcinoma of parotid gland a case. Lymphoepithelioma is a type of poorly differentiated nasopharyngeal carcinoma characterized by prominent infiltration of lymphocytes in the area involved by tumor. Lymphoepithelial carcinoma lec is a rare malignancy with the. However, no risk factor is known for lelc of the bladder 4. Lymphoepithelial carcinoma of salivary glands lymphoepithelial carcinoma of salivary glands abdulla, abdel. Primary lymphoepithelial carcinoma plec is a very unusual subtype of salivary gland cancers, which involves mainly the parotid gland1,2.
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